Capt. Larry Horton said it appears the fire gutted the Lakeside Coffee House & Princess Cupcakes, 1604 Martin Street South, Suite 3.
He said adjoining businesses sustained smoked damaged, but the fire was contained to the right side of the building.
The fire was reported at about 6:30 p.m.
Police blocked a portion of the northbound lanes of U.S. 231 while firefighters extinguished the fire.
Other businesses in the structure were Steven & Son Locksmith and the Rustic Rooster, an antique store.
The fire is still under investigation.
Nobody was injured in the blaze.
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